Response to “HIV Escape From RNAi Antivirals: Yet Another Houdini Action?”

HIV-1 Escape From RNAi Antivirals: Yet Another Houdini Action?

To the Editor: Since the identification of HIV-1 as the primary cause of AIDS, much effort has been made to develop therapies that potently inhibit virus replication. Unfortunately, HIV-1 uses an error-prone replication machinery that allows the virus to rapidly adapt to new conditions. As a consequence , early single-drug therapies failed because of the rapid appearance of drug-resistant virus...

Response to “HIV Escape From RNAi Antivirals: Yet Another Houdini Action?”

To the Editor: In his 1909 book Handcuff Secrets, Harry Houdini lifted the shroud of secrecy surrounding his performances and revealed that his mystifying capacity to escape shackles and chains was based in painstaking effort and compromise. Shaking off straightjackets for example required dislocating his shoulders, performance after performance, year after year. In the current issue of Molecul...

Yet Another Modular Action Language

The paper presents the syntax and semantics of an action language ALM. The language is used for representation of knowledge about dynamic systems. It extends action language AL by allowing definitions of new objects (actions and fluents) in terms of other, previously defined, objects. This, together with the modular structure of the new language leads to more elegant and concise representations...

Yet another perspective: a response to Connolly

Yet Another Visit to Paxos

This paper presents a modular introduction to crash-tolerant and Byzantine-tolerant protocols for reaching consensus that use the method introduced by the Paxos algorithm of Lamport and by the viewstamped replication algorithm of Oki and Liskov. The consensus protocol runs a sequence of epoch abstractions as governed by an epoch-change abstraction. Implementations of epoch and epoch-change that...